Endocrine Abstracts

Background: Diabetic nephropathy (DN) is a major cause of morbidity and mortality in type 1 diabetes (T1D) patients and associated with increased cardiovascular risk in type 2 diabetes (T2D) patients. Early detection of DN using neutrophil gelatinase-associated lipocalin (NGAL) assessment can help to reveal predisposed patients to its progression and to prevent progression of DN. Especially important it is in patients with normoalbuminuria.Aim: To determ...

The concept of a subclinical form of diabetic peripheral neuropathy (DPN) is well established. Although there has been considerable research of peripheral neuropathy in type 1 diabetes, still there is controversy regarding the pattern of nerve involvement in diabetic neuropathy. Detection of the pattern of nerve involvement can help to establish a protocol for screening of DPN in its subclinical stage.Aim: The aim of this study was to describe the patter...

Introduction: Preserving of C-peptide secretion in type 1 diabetes mellitus (DM1) is an important goal in treatment, as it provides the possibility of optimal compensation. We initiated a study (ClinicalTrials.gov 26.01.2022, NCT05207995) to assess the potential effect of Tolerant Dendritic Cells (tolDC) on the newly diagnosed DM1.Methods: Evaluation of stimulated C-peptide against the background of a standard breakfast (carbohydrate content of 50g) was ...